Society of Cosmetic Chemists

Senior Analytical Chemist

Abterra Biosciences
San Diego, California, United States
7 days ago

Description

Abterra Biosciences is a growing biotechnology startup developing a novel platform for mining the human immune response for the next-generation of antibody therapeutics. Abterra Bio utilizes next-generation sequencing to decode the cellular antibody repertoire and the latest proteomics techniques to analyze the functional serum repertoire. We are a multi-disciplinary
team seeking individuals that want to unlock the human immune system to deliver life saving therapeutics.

Responsibilities:
● Operate and maintain nano-flow liquid chromatography and high-resolution mass spectrometry (Orbitrap Eclipse) instrumentation.

● Develop and validate of tandem MS-based analytical methods and standard operating procedures (SOPs) for discovery and targeted proteomics of complex antibody samples.

● Develop SOPs for LC-MS maintenance, operation and troubleshooting in a production setting.

● Collaborate with bioinformaticians and biologists to achieve technology milestones.

● Stay up to date on relevant literature in protein mass spectrometry, antibody discovery, and related areas.

● Communicate methods and results in presentations, publications, and posters.

● Contribute to intellectual property portfolio.



Requirements

Required Skills:
● PhD in chemistry, biochemistry, or similar with 3+ years of post-graduate work.

● Experience designing and implementing in-solution and in-gel digestion approaches to enable workflows for discovery proteomics.

● Strong analytical and practical skills in protein sample preparation and nano-LC-HRMS for proteomic analysis.Experience with Orbitrap type instrumentation and in-depth knowledge of instrument calibration, operation, troubleshooting, and maintenance (i.e. Q-Exactive, Orbitrap Fusion Lumos, Orbitrap Eclipse).

● Experience with various standard in-solution and in-gel proteomic sample prep protocols for bottom-up proteomic workflows.

● Ability to pick up new technologies quickly and troubleshoot independently.

● Proven track record of independent critical thinking, scientific achievement, and the ability to interact creatively and collaboratively with relevant departments.

Desired Skills:
● Experience with handling human as well as animal biomatrices (plasma/serum).

● Excellent analytical chemistry skills with a working knowledge and hands-on experience developing bottom-up and top/middle-down proteomic workflows using nano-flow LC-MS systems.

● Experience with labeled (TMT or iTRAQ) and label-free quantitative proteomic approaches (i.e. data-independent acquisition).

● Experience with data analysis software platforms, as well as third-party software platforms such as Max Quant, Trans-Proteomic Pipeline, Skyline, and Scaffold.

● Expertise with FPLC protein purification techniques such as IMAC, SEC, IEX, HIC.

● Expertise in preparing samples and performing liquid chromatography fractionation.

● Experience with high-throughput quantitative proteomic approaches; including sample multiplexing and modern liquid chromatography fractionation techniques.

Job Information

  • Job ID: 59209812
  • Location:
    San Diego, California, United States
  • Position Title: Senior Analytical Chemist
  • Company Name: Abterra Biosciences
  • Job Function: Res. & Dev. Scientist
  • Job Type: Full-Time
  • Job Duration: Indefinite
  • Min Education: 1
  • Min Experience: 2-3 Years
  • Required Travel: 0-10%

Please refer to the company's website or job descriptions to learn more about them.

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